脊髓
少突胶质细胞
谱系(遗传)
神经科学
中枢神经系统
脊髓损伤
生物
祖细胞
偏爱
电池类型
祖细胞
感觉系统
细胞
干细胞
髓鞘
遗传学
基因
经济
微观经济学
作者
Elisa M. Floriddia,Tânia Lourenço,Shupei Zhang,David van Bruggen,Markus M. Hilscher,Petra Kukanja,João Pedro Gonçalves dos Santos,Müge Altınkök,Chika Yokota,Enric Llorens-Bobadilla,Sara B. Mulinyawe,Mário Grãos,Lu Sun,Jonas Frisén,Mats Nilsson,Gonçalo Castelo‐Branco
标识
DOI:10.1038/s41467-020-19453-x
摘要
Abstract Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease.
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