串扰
生物
肠道微生物群
分解代谢
免疫系统
计算生物学
微生物代谢
微生物群
疾病
新陈代谢
生物化学
寄主(生物学)
细菌
代谢组学
代谢组
代谢途径
生物信息学
免疫学
生态学
遗传学
医学
病理
物理
光学
作者
Yali Liu,Yuanlong Hou,Guangji Wang,Xiao Zheng,Haiping Hao
标识
DOI:10.1016/j.tem.2020.02.012
摘要
Gut microbial metabolism is intimately coupled with host health and disease. Aromatic amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may regulate immune, metabolic, and neuronal responses at local and distant sites. Such a chemical dialog between host cells and the gut microbiome is shaped by environmental cues, and may become dysregulated in gastrointestinal and systems diseases. Increasing knowledge of the bacterial pathway and signaling basis may shed additional light on metabolic host-microbiome crosstalk that remains untapped for drug discovery. Here, we update our understanding of microbial AAA metabolism and its impacts on host physiology and disease. We also consider open questions related to therapeutically mining these signaling metabolites and how recent concepts and tools may drive this area forward.
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