生物
计算生物学
细胞谱系
单细胞测序
发育生物学
干细胞
追踪
谱系(遗传)
进化生物学
遗传学
计算机科学
细胞分化
基因
表型
外显子组测序
操作系统
作者
Daniel E. Wagner,Allon M. Klein
标识
DOI:10.1038/s41576-020-0223-2
摘要
A fundamental goal of developmental and stem cell biology is to map the developmental history (ontogeny) of differentiated cell types. Recent advances in high-throughput single-cell sequencing technologies have enabled the construction of comprehensive transcriptional atlases of adult tissues and of developing embryos from measurements of up to millions of individual cells. Parallel advances in sequencing-based lineage-tracing methods now facilitate the mapping of clonal relationships onto these landscapes and enable detailed comparisons between molecular and mitotic histories. Here we review recent progress and challenges, as well as the opportunities that emerge when these two complementary representations of cellular history are synthesized into integrated models of cell differentiation.
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