化学
药物发现
介绍(产科)
Nexus(标准)
计算生物学
纳米技术
鉴定(生物学)
数据科学
计算机科学
生物
生物化学
生态学
医学
放射科
嵌入式系统
材料科学
作者
Dillon T. Flood,Cian Kingston,Julien C. Vantourout,Philip E. Dawson,Phil S. Baran
标识
DOI:10.1002/ijch.201900133
摘要
Abstract In 1992, Brenner and Lerner hypothesized that individual chemical transformations could be encoded in DNA, allowing the rapid synthesis and screening of large collections of small molecules. Since their report, huge investments into the development of the DNA encoded library (DEL) technology have enabled the acceleration of the drug discovery process especially early phase discovery undertakings such as target validation and hit identification. As DEL lies at the nexus between chemistry and biology, there is an increasing need to expand the toolboxes of both organic transformations and biological methods. However, the myriad of techniques and reactions already reported can be difficult to digest for practitioners whose expertise resides outside the realm of DEL. This review therefore focuses on a stepwise presentation of DEL from the basic concepts to newest developments. The presentation includes the history, fundamentals, and successes of DEL, different methods for DEL synthesis and affinity selection, the conventional transformations, and finally the latest developments from a synthetic organic perspective.
科研通智能强力驱动
Strongly Powered by AbleSci AI