Redox-neutral photocatalytic cyanomethylation/cyclization cascade of olefinic amides: Access to cyanomethylated benzoxazines

A visible-light-induced photocatalytic cyanomethyl radical addition/intramolecular cyclization cascade reaction of olefinic amides has been developed under mild conditions. This reaction provides a novel method for the synthesis of various cyanomethyl-containing benzoxazines, which are useful pharmaceutical framework. The method exhibits good functional group tolerance and a wide range of substrate scope.