肉豆蔻
DPPH
抗氧化剂
化学
脂肪酶
胰脂肪酶
抗坏血酸
传统医学
效力
奥利斯特
生物化学
体外
药理学
食品科学
酶
肥胖
生物
医学
内分泌学
减肥
作者
Yakaiah Vangoori,Anusha Dakshinamoorthi,S. Kavimani
出处
期刊:PubMed
日期:2019-09-01
卷期号:14 (3): 254-259
被引量:1
标识
DOI:10.26574/maedica.2019.14.3.254
摘要
Objective:The objective of the present study was to evaluate the antioxidant and lipase inhibitory potential of various extracts of Myristica fragrans (in vitro). Material and methods:Ethanolic extracts of Myristica fragrans were studied for their free radical scavenging and lipase inhibitory potentials by using porcine lipase, PNPB and DPPH. All results were obtained by applying active formulas and calculating the percentage of inhibition. Results:Among all extracts, Myristica fragrans ethanolic extract has shown the strongest pancreatic lipase inhibitory activity at 100 ìg/mL (66.24%), with the closest potency to tthat of the standard drug, Orlistat (81.57%). This extract has also exhibited a potent antioxidant activity. The findings of the present study clearly showed that DPPH free radical scavenging activity of MFE produced 88% inhibition at 5 mg/mL as compared to standard ascorbic acid, which was 90%. Conclusions:Ethanolic extracts of Myristica fragrans had a marked PL inhibitory action and antioxidant effect. Therefore, based on this research evidence, they could be aternatively used for obesity treatment.
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