Lectin-like oxidized low-density lipoprotein receptor-1 and ischemic stroke

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a member of C-type lectin-like receptor family. It can recognize many ligands and is the main receptor of oxidized low-density lipoprotein for inducing vascular endothelial dysfunction. Early studies focused on the role of LOX-1 in atherosclerosis and diabetes mellitus. Recent studies have shown that LOX-1 is closely associated with ischemic stroke. This article reviews the biological characteristics of LOX-1 and its association with ischemic stroke. Key words: Stroke; Brain ischemia; Scavenger receptors, class E; Receptors, oxidized LDL; Risk factors