Photoredox/Ti Dual‐Catalyzed Dehydroxylation of Cyclobutanone Oximes for γ‐Cyanoalkyl Radical Generation: Access to Cyanoalkyl‐Substituted Oxoindolines

Abstract In this work, we have established a photoredox/Ti dual‐catalyzed dehydroxylation of cyclobutanone oximes. The resulting γ‐cyanoalkyl radicals undergo a cascade radical addition/cyclization with N ‐acrylamides to afford cyanoalkyl substituted oxoindolines under mild conditions. This reaction also exhibits broad substrate scope and good functional group tolerance. Furthermore, it is applicable to late‐stage functionalization of complex molecules and gram‐scale synthesis, which illustrates its potential value in organic synthesis. magnified image