医学
头颈部
淋巴结
头颈部鳞状细胞癌
病理
癌
淋巴结转移
转移
鉴别诊断
头颈部癌
放射科
内科学
放射治疗
癌症
外科
作者
Komkrit Ruangritchankul,Ann Sandison
出处
期刊:Advances in Anatomic Pathology
[Ovid Technologies (Wolters Kluwer)]
日期:2022-10-12
卷期号:30 (2): 86-94
被引量:4
标识
DOI:10.1097/pap.0000000000000376
摘要
A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. The tumors occurred at multiple sites in the head and neck including in the sinonasal tract, middle ear, and temporal bone. This tumor behaves aggressively involving adjacent vital structures, frequently recurs, and is inclined to develop lymph node and distant metastasis. This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and pattern of molecular alterations as well as to discuss the differential diagnosis of DEK::AFF2 fusion carcinoma.
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