吲哚试验
区域选择性
色氨酸
戒指(化学)
化学
仿生合成
全合成
骨架(计算机编程)
立体化学
氧化磷酸化
催化作用
有机化学
氨基酸
生物化学
生物
解剖
作者
Xikang Zheng,Yan Li,Mengtie Guan,Lingyue Wang,Shilong Wei,Yicheng Li,Chin-Yuan Chang,Zhengren Xu
标识
DOI:10.1002/anie.202208802
摘要
A unified strategy for the biomimetic total synthesis of the spiroindimicin family of natural products was reported. Key transformations include a one-pot two-enzyme-catalyzed oxidative dimerization of L-tryptophan/5-chloro-L-tryptophan to afford the bis-indole precursors chromopyrrolic acid/5',5''-dichloro-chromopyrrolic acid, and regioselective C3'-C2'' and C3'-C4'' bond formation converting a common bis-indole skeleton to two skeletally different natural products, including (±)-spiroindimicins D and G with a [5,5] spiro-ring skeleton, and (±)-spiroindimicins A and H with a [5,6] spiro-ring skeleton, respectively.
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