NLRP3 inhibition protects human coronary endothelial cells from oxidative and lipotoxic stress

and PA significantly impaired in vitro pseudocapillary formation by HCAECs and HUVECs, considered the gold standard for in vitro angiogenesis assays, an effect counteracted by INF195. These findings suggest that, under oxidative and lipotoxic stress, NLRP3 inflammasome inhibition -particularly via INF195 - supports the maintenance of vascular endothelial homeostasis by preserving cell viability and angiogenic function.