Comprehensive Analysis Identifies Tumor Mutation Burden-associated Genes ASPM and KIF11 as Novel Biomarkers for Adrenocortical Carcinoma

A total of eight candidate TMB-related prognostic genes (including ASPM, BIRC5, BUB1, CDC20, CDCA5, CEP55, KIF11, and TPX2) for ACC patients were identified. Preliminary experimental verification revealed that ASPM and KIF11 could promote the proliferation of ACC cells and ACC tumor growth in vivo.