干细胞
髓系白血病
血液学
癌症研究
内科学
医学
肿瘤科
生物
遗传学
作者
Yi Zhang,Miso Park,Lucy Ghoda,Dandan Zhao,Melissa Valerio,Ebtesam Nafie,Asaul Gonzalez,Kévin Ly,Bea Parcutela,Hyeran Choi,Xubo Gong,Fang Chen,Kaito Harada,Zhenhua Chen,Le Xuan Truong Nguyen,Flavia Pichiorri,Jianjun Chen,Joo Y. Song,Stephen J. Forman,Idoroenyi Amanam
标识
DOI：10.1186/s13045-024-01586-x
摘要
The interleukin-1 receptor accessory protein (IL1RAP) is highly expressed on acute myeloid leukemia (AML) bulk blasts and leukemic stem cells (LSCs), but not on normal hematopoietic stem cells (HSCs), providing an opportunity to target and eliminate the disease, while sparing normal hematopoiesis. Herein, we report the activity of BIF002, a novel anti-IL1RAP/CD3 T cell engager (TCE) in AML.
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(2025-6-4)
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