被盖腹侧区
神经科学
多巴胺
刺激(心理学)
钙显像
生物
心理学
内科学
认知心理学
医学
多巴胺能
钙
作者
Lindsay Willmore,Adelaide R. Minerva,Ben Engelhard,Malavika Murugan,Brenna McMannon,Nirja Oak,Stephan Y. Thiberge,Catherine J. Peña,Ilana B. Witten
出处
期刊:Neuron
[Elsevier]
日期:2023-11-01
卷期号:111 (22): 3541-3553.e8
被引量:11
标识
DOI:10.1016/j.neuron.2023.08.003
摘要
Dopamine neurons of the ventral tegmental area (VTADA) respond to food and social stimuli and contribute to both forms of motivation. However, it is unclear whether the same or different VTADA neurons encode these different stimuli. To address this question, we performed two-photon calcium imaging in mice presented with food and conspecifics and found statistically significant overlap in the populations responsive to both stimuli. Both hunger and opposite-sex social experience further increased the proportion of neurons that respond to both stimuli, implying that increasing motivation for one stimulus increases overlap. In addition, single-nucleus RNA sequencing revealed significant co-expression of feeding- and social-hormone-related genes in individual VTADA neurons. Taken together, our functional and transcriptional data suggest overlapping VTADA populations underlie food and social motivation.
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