神经心理学
痴呆
认知
脑血流
神经影像学
正电子发射断层摄影术
认知功能衰退
医学
睡眠剥夺对认知功能的影响
磁共振成像
心理学
神经科学
听力学
内科学
疾病
放射科
作者
Sophia L. Holmqvist,Kelsey R. Thomas,Emily C. Edmonds,Amanda Calcetas,Lauren Edwards,Katherine J. Bangen
出处
期刊:Journal of The International Neuropsychological Society
[Cambridge University Press]
日期:2022-09-12
卷期号:29 (7): 621-631
被引量:3
标识
DOI:10.1017/s1355617722000649
摘要
Abstract Objective: Cognitive dispersion across neuropsychological measures within a single testing session is a promising marker predictive of cognitive decline and development of Alzheimer’s disease (AD). However, little is known regarding brain changes underlying cognitive dispersion, and the association of cognitive dispersion with in vivo AD biomarkers and regional cerebral blood flow (CBF) has received limited study. We therefore examined associations among cognitive dispersion, amyloid-beta (Aβ) positivity, and regional CBF among older adults free of dementia. Method: One hundred and forty-eight Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants underwent neuropsychological testing and neuroimaging. Pulsed arterial spin labeling (ASL) magnetic resonance imaging (MRI) was acquired to quantify CBF. Florbetapir positron emission tomography (PET) imaging determined Aβ positivity. Results: Adjusting for age, gender, education, and mean cognitive performance, older adults who were Aβ+ showed higher cognitive dispersion relative to those who were Aβ-. Across the entire sample, higher cognitive dispersion was associated with reduced CBF in inferior parietal and temporal regions. Secondary analyses stratified by Aβ status demonstrated that higher cognitive dispersion was associated with reduced CBF among Aβ+ individuals but not among those who were Aβ-. Conclusions: Cognitive dispersion may be sensitive to early Aβ accumulation and cerebrovascular changes adjusting for demographics and mean neuropsychological performance. Associations between cognitive dispersion and CBF were observed among Aβ+ individuals, suggesting that cognitive dispersion may be a marker of brain changes among individuals on the AD continuum. Future studies should examine whether cognitive dispersion predicts brain changes in diverse samples and among those with greater vascular risk burden.
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