髓系白血病
药效团
化学
白血病
串扰
癌症研究
药理学
细胞凋亡
生物化学
生物
免疫学
光学
物理
作者
Guanlu Long,Xianghan Wang,Xin Chen,Sai Ma,Liangkui Sun,Zhengyu Jiang,Qidong You,Xiaoke Guo
标识
DOI:10.1021/acs.jmedchem.4c01720
摘要
was well tolerated, inhibiting MV-4-11 xenograft growth by 87.1%. Our investigation established the therapeutic effectiveness of the developed WDR5-MLL1/HDAC dual-target inhibitor against acute myeloid leukemia, providing a valuable tool for further exploration of crosstalk between the two targets.
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