The hemispheric differences in prefrontal function of Internet game disorder and non-Internet game disorder: an activation likelihood estimation meta-analysis

This study explored the differences in brain activation between individuals with and without Internet gaming disorder (IGD) through activation likelihood estimation analysis. In total, 39 studies were included based on the inclusion and exclusion criteria by searching the literature in the PubMed and Web of Science databases, as well as reading other reviews. The analysis revealed that the activated brain regions in IGD were the right inferior frontal gyrus, left cingulate gyrus, and left lentiform nucleus. In comparison, the activated brain regions in non-IGD were the left middle frontal, left inferior frontal, left anterior cingulate, left precentral, and right precentral gyri. The results of the present study on differences in activation further confirm existing theoretical hypotheses. Future studies should explore hemispheric differences in prefrontal brain function between IGD and non-IGD.