Aloe vera polysaccharides mitigate high-fat high-cholesterol diet-induced atherosclerosis in ApoE−/− mice via regulation of lipid metabolism and gut microbiota

, may partially mediate the effects of AVP through the gut-liver axis. This is the first study to report the atheroprotective effects of AVP, demonstrating that it alleviates atherosclerosis by restoring lipid metabolism homeostasis and modulating the gut microbiome.