区域选择性
化学
酰胺
催化作用
光催化
组合化学
功能群
表面改性
基质(水族馆)
反应条件
群(周期表)
氰化物
取代反应
范围(计算机科学)
纳米技术
金属
反应机理
钯
有机化学
高分子化学
分子
作者
Enfan Pu,Yanren Zhu,Shaoxiong Yang,P. Jiang,Xiong Li,Hongbin Zhang,Jingbo Chen
出处
期刊:Organic Letters
[American Chemical Society]
日期:2025-09-13
卷期号:27 (38): 10855-10861
被引量:2
标识
DOI:10.1021/acs.orglett.5c03473
摘要
Herein we report a metal-free photocatalytic three-component Minisci-type reaction that simultaneously installs both amide and cyanopyridine functionalities into alkenes in a single step. This strategy enables rare C2-selective functionalization of 4-cyanopyridines, exhibiting regioselectivity complementary to ipso substitution at C4. This protocol proceeds under mild conditions and retains the cyano group with broad substrate scope and excellent functional group compatibility, while the absence of cyanide release and metal catalysts aligns with contemporary green chemistry principles.
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