Inorganic Biomaterials Inducing Scaffolds Pre‐Neuralization for Infarcted Myocardium Repair

Neural networks are found to play an important role in monitoring and coordinating cardiac physiological activities. However, the clinical use of neuroregulatory strategies for repairing infarcted myocardium, such as vagus nerve stimulation and pharmacological activation, confronts the challenges of managing stimulation signals and potential drug side effects. In this study, an innovative myocardial infarction repair strategy by creating a "pre-neuralized" scaffold that combines strontium silicate microparticles with neural stem cells (NSCs) is introduced. Strontium silicate promotes NSCs differentiation, resulting in a scaffold enriched with mature neurons. This scaffold exhibits neuroregulatory capabilities that enhance the maturation and synchronized contraction of cardiomyocytes, facilitating myocardial repair and improving cardiac function in vivo. The findings indicate that the pre-neuralized scaffold aids myocardial recovery by modulating genes linked to circadian rhythm, underscoring the strategic benefit of neural-induced regulation in tissue repair. In conclusion, this study presents a promising approach to repairing infarcted myocardium using inorganic biomaterial-induced scaffolds with neuromodulatory properties from the perspective of systemically physiological regulation. This work may offer a new perspective for addressing complex tissue and organ injuries.