内科学
细胞毒性T细胞
医学
酒精性肝病
CD8型
生物
化学
内分泌学
免疫学
免疫系统
生物化学
肝硬化
体外
作者
Luca Maccioni,Yukun Guan,Mariia Kim,Maria A. Parra,Brandon Peiffer,Yaojie Fu,Yang Wang,Yuhong Lin,Bryan Mackowiak,Dechun Feng,Andrew M. Cameron,Zhaoli Sun,George Kunos,Peter Stärkel,Bin Gao
出处
期刊:Gut
[BMJ]
日期:2025-04-08
卷期号:74 (8): 1308-1320
被引量:15
标识
DOI:10.1136/gutjnl-2024-334412
摘要
BACKGROUND: Gut-liver crosstalk plays an important role in alcohol-associated liver disease (ALD) pathogenesis; but underlying mechanisms remain obscure. OBJECTIVE: T lymphocytes and their contribution to ALD. DESIGN: mice were subjected to chronic-plus-binge ethanol feeding. RESULTS: T cells, improved gut barrier function and ameliorated ALD, while CD8 deficiency was linked to enhanced neutrophil and macrophage infiltration in the liver, exacerbating ALD in mice. CONCLUSIONS: T cells may represent a novel therapeutic strategy for ALD patients.
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