A Real-Time Plasma Concentration Prediction Model for Voriconazole in Elderly Patients via Machine Learning Combined with Population Pharmacokinetics

Our study is the first to incorporate pharmacokinetic parameters into ML models to predict VCZ plasma concentrations in elderly patients. The model was optimized using feature selection and may serve as a reference for individualized VCZ dosing in clinical practice, thereby enhancing the efficacy and safety of VCZ treatment in elderly patients.