Integrating network pharmacology and transcriptomics reveals that Bushen Huoxue recipe ameliorates ferroptosis and apoptosis in granulosa cells by regulating PI3K/Akt signaling pathway in premature ovarian insufficiency mice

BHR effectively ameliorated ovarian function in CTX-induced POI mice by suppressing ferroptosis and apoptosis in GCs. This effect is mechanistically mediated by the activation of the PI3K/Akt signaling pathway. Furthermore, the Hmox1/GPX4 axis may be associated with BHR-mediated inhibition of ferroptosis.