Comparison of the Effects of Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Injection and CO2 Fractional Laser on Atrophic Acne Scar in Asians Through a 24‐Week Prospective, Randomized, Split‐Face Study

BACKGROUND: Adipose extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) contains adipose-derived stem cells, extracellular matrix, and other cell components, and possesses the ability to promote collagen production and serve as a filling agent. AIM: FL). METHODS: FL treatments on the other half. The primary outcome was the change in total Echelle d'Evaluation Clinique des Cicatrices d'acne (ECCA) score from baseline to 24-week follow-up. Secondary outcomes included the changes in the volume of scars assessed by the Antera 3D software. RESULTS: FL (difference: -13.48% [95% CI:-22.16% to -4.79%], p = 0.004). CONCLUSIONS: ECM/SVF-gel injection is an effective and safe approach in the treatment of acne scars. TRIAL REGISTRATION: ClinicalTrials.gov number: NCT06116162.