纳米载体
生物利用度
医学
纳米医学
药理学
治疗指标
他汀类
纳米技术
药品
材料科学
内科学
纳米颗粒
作者
Leila Etemad,Zahra Salmasi,Seyedeh Alia Moosavian Kalat,Mohammad Moshiri,Javad Zamanian,Prashant Kesharwani,Amirhossein Sahebkar
标识
DOI:10.1016/j.envres.2023.116572
摘要
Statins are the most widely used pharmacological agents for reducing blood cholesterol levels and treating atherosclerotic cardiovascular diseases. Most of the statins' derivatives have been limited by water solubility, bioavailability, and oral absorption, which has led to adverse effects on several organs, especially at high doses. As an approach to reducing statin intolerance, achieving a stable formulation with improved efficacy and bioavailability at low doses has been suggested. Nanotechnology-based formulations may provide a therapeutic benefit over traditional formulations in terms of potency and biosafety. Nanocarriers can provide tailored delivery platforms for statins, thereby enhancing the localized biological effects and lowering the risk of undesired side effects while boosting statin's therapeutic index. Furthermore, tailored nanoparticles can deliver the active cargo to the desired site, which culminates in reducing off-targeting and toxicity. Nanomedicine could also provide opportunities for therapeutic methods by personalized medicine. This review delves into the existing data on the potential improvement of statin therapy using nano-formulations.
科研通智能强力驱动
Strongly Powered by AbleSci AI