POS0499 DIFFERENCES IN FRACTURE RISK IN PATIENTS WITH DISCORDANT BONE MINERAL DENSITY IN THE HIPS: OBSERVATIONAL STUDY

Background

Osteoporosis is a condition characterised by low bone mineral density (BMD) and is associated with increased risk of fractures and subsequent increased morbidity and mortality. The usual sites of BMD measurements are either the non-dominant hip or the spine. The hip is used to predict fracture risk using the FRAX™ tool. Some patients have a different BMD as shown by their T scores in the contralateral hip.

Objectives

This study aimed to ascertain whether patients significantly discordant in their BMD on the contralateral hip have a different risk for fractures.

Methods

Data from a dual-energy x-ray absorptiometry (DEXA) scanner in the North West of England were used. Patients who were referred between 2004-2011 were studied. Patients had both hips scanned as well as risk factors and presence of fracture recorded. Data collected included age, sex, height, weight, BMI, history of fractures, rheumatoid arthritis status, smoking status, alcohol use and malabsorption. Those that had a BMD T-score difference of either greater than or equal +1 SD or -1SD were considered to have discordant hips. These two groups were compared using independent sample t-tests for continuous variables and chi-squared tests for categorical variables. Logistic models were then fitted to look at the odds of fracture in each group.

Results

The hip T-scores of 35759 patients were measured. Mean age was 62.17 (±12.78) with 84.16% being female. There were 15287 (42.75%) who had discordant hips. The odds ratio for the measured risk factors and the association with fracture are shown in Table 1 below.

Conclusion

Hip discordance might be associated with adverse risk factors such as increased frequency of fractures. Measuring BMD of both hips could give a better estimate of future fracture risk. Further analysis of a subset from this group will be explored and presented.

REFERENCES:

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Acknowledgements:

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Disclosure of Interests

None Declared.