医学
宫颈上皮内瘤变
细胞学
宫颈癌
组织病理学
妇科
内科学
预测值
阴道镜检查
癌症
肿瘤科
胃肠病学
病理
作者
Yang Li,Tao Hong,Bin Lin,Xijing He,Yibo Chen,Xing Fan
出处
期刊:Future Oncology
[Future Medicine]
日期:2023-09-01
卷期号:19 (28): 1917-1927
标识
DOI:10.2217/fon-2023-0226
摘要
Aim: To evaluate the clinical performance of PAX1 methylation (PAX1m) and cytology for patients with non-HPV16/18 high-risk HPV (hrHPV) infection. Methods: Cervical exfoliated cells from 387 outpatients with non-HPV16/18 hrHPV - positive were collected for cytology and PAX1m assays. Results: The PAX1m level increased with the severity of cytology and histopathology. For cervical intraepithelial neoplasia (CIN)CIN2+/CIN3+, the areas under the curve were both 0.87. The specificity and positive predictive value (PPV) of PAX1m were greater than abnormal cytology (CIN2+ specificity: 75.5 vs 24.8%; PPV: 38.8 vs 18.7%; CIN3+ specificity: 69.3 vs 22.7%; PPV: 14.0 vs 6.7%). Conclusion:PAX1m increased specificity and PPV for CIN2+/CIN3+ compared with cytology for women with non-HPV16/18 hrHPV (+).
科研通智能强力驱动
Strongly Powered by AbleSci AI