泡叶藻
多酚
紫外线b
氧化损伤
RPE65型
化学
视网膜
氧化磷酸化
紫外线
氧化应激
植物
生物化学
生物
抗氧化剂
医学
藻类
视网膜色素上皮
材料科学
光电子学
皮肤病科
作者
Yu‐Jing Lu,Ping Shen,Luhong Bai,Cheng‐Hang Sun,Rong Tian,Xiang Li,Honglan Qi
标识
DOI:10.1016/j.jff.2024.106067
摘要
Long-term exposure to sunlight, especially ultraviolet (UV), induces eye injury in people. We investigated the protective potential of Polyphenolic extract from Ascophyllum nodosum (PEAn) against UV-B-induced oxidative damage in retinal Müller cells (RMCs). In the UV-B-induced damage model of RMCs, PEAn demonstrated a potent photoprotective effect that reduced oxidative damage and apoptosis. PEAn significantly regulated the concentrations of ROS, Caspase-3, and Calcium ions (Ca2+) in RMCs generated by UV-B. The mitochondrial membrane potential (ΔΨm) and activities of various antioxidant enzymes (SOD, CAT, and GSH-Px) were significantly increased, whereas the MDA was reduced. Lipidomic research in RMCs also revealed that UV-B irradiation significantly altered the lipid compounds in the cells, while PEAn therapy gradually restored normal cells. Both the accumulation of triacylglycerides and the toxicity of the lipids in RMCs were simultaneously reduced by PEAn. The findings indicated that PEAn could be a potential natural photochemical protectant against UV-B-induced oxidative damage.
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