无乳链球菌
磷酸戊糖途径
代谢组
肺炎链球菌
微生物学
轻度链球菌
链球菌
代谢组学
代谢途径
化学
生物
新陈代谢
细菌
生物化学
糖酵解
生物信息学
抗生素
遗传学
作者
Tian Liang,Xueqi Wang,Lele Chen,Ling Ding,Jianping Wu,Ji Zhang,Rongming Wang
标识
DOI:10.1016/j.fbio.2023.103528
摘要
Streptococcus agalactiae (Group B Streptococcus, GBS), is one of the primary pathogens causing bovine mastitis. It is also a major cause of invasive neonatal infections such as meningitis, pneumonia, and bacteremia. In this study, the antibacterial effect of Zantheoxylum bungeanum essential oil (ZBEO) against GBS was evaluated through determination of minimum inhibitory concentration (MIC) and microstructure observation. Additionally, an integrated analysis of transcriptomics and metabolomics was conducted after treatment with ZBEO. Results showed that ZBEO had a good inhibitory effect on GBS and significant effects on its transcription and metabolic levels. We found that ZBEO can disrupt the physiological metabolism of GBS by inhibiting peptidoglycan biosynthesis, disrupting lipid metabolism, limiting amino acid metabolism, inhibiting the tricarboxylic acid cycle, and inhibiting the pentose phosphate pathway. These findings provide a theoretical basis for ZBEO as a novel natural antibacterial agent against microbial infections.
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