医学
过敏
过敏原
过敏性接触性皮炎
生物标志物
接触性皮炎
罪魁祸首
皮肤病科
免疫学
特应性皮炎
斑贴试验
接触性过敏
内科学
生物化学
化学
心肌梗塞
作者
Mathieu Lefèvre,Audrey Nosbaum,A. Mosnier,Vanina Lenief,Samuel SALQUE,Marie PICHOT,Lea MAHEUX,L. Bertolotti,F. Hacard,C. Graveriau,P. Zukervar,Anne-Laure BRETON GUITARIAN,Fanny Boislève,M. Elbaz,Jean Francois Daniel Nicolas,Marc Vocanson
标识
DOI:10.1016/j.jaad.2023.11.066
摘要
Background Distinguishing between allergic and non-allergic forms of Contact Dermatitis (CD) is challenging and requires investigations based on patch-testing. Early detection of allergy biomarkers in active CD lesions could refine and simplify the management of CD patients. Objective To characterize the molecular signatures of active CD lesions. Methods We studied the expression of 12 allergy biomarkers by qRT-PCR in active lesions of 38 CD patients. Allergic CD (ACD) was diagnosed based on patch-test (PT) results and exposure assessment. Molecular signatures of active lesions, as well as positive PT reactions, were compared with those of reference chemical allergens and irritants. Results 19 of the 38 CD patients reacted positively upon patch-testing and exposure assessment confirmed ACD diagnosis for 17 of them. Gene profiling of active CD lesions revealed two distinct molecular patterns: patients harboring signatures similar to reference allergens (n=23) or irritants (n=15). Among the 23 patients with an “allergy signature”, we found the 17 patients with confirmed ACD, while no culprit allergen was identified for the 6 other patients. Interestingly, the 15 patients without biomarker induction had negative PT, suggesting that they developed non-allergic CD reactions. Conclusion Molecular signatures from active skin lesions may help to stratify CD patients and predict those suffering from allergic contact dermatitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI