自愈水凝胶
组织工程
纳米技术
再生医学
仿生材料
仿生学
药物输送
软质材料
生物医学
材料科学
计算机科学
生物医学工程
工程类
化学
生物信息学
生物
生物化学
高分子化学
细胞
作者
Song-Qing Hu,Chen Zeng,Yuchen Jiang,Weiqing Kong,Meifang Zhu
标识
DOI:10.1021/acs.chemmater.3c02098
摘要
The field of tissue engineering and regenerative medicine is rapidly advancing, with numerous novel and intriguing biomimetic materials being reported. Hydrogels, due to their unique structure and properties closely resembling biological tissues, stand as prime candidates for mimicking natural tissues in tissue engineering and regenerative medicine applications. In recent years, drawing inspiration from the intricate structures found in biological soft tissues, researchers have successfully created a range of biomimetic hydrogels. These hydrogels have been tailored for diverse applications in fields such as biomedicine, tissue engineering, flexible electronic devices, and beyond. However, designing and fabricating biomimetic synthetic materials with intricate structures, dynamic microenvironment systems, and integrated functionalities remains challenging. This article presents the latest research progress in macroscopic structural biomimetic hydrogels, as well as microenvironment biomimetic hydrogels, along with the most recent construction strategies, key design principles, and optimization mechanisms. It summarizes their potential applications in various domains such as tissue repair, signal detection and sensing, drug delivery, and more. Lastly, the challenges and future development directions in the preparation and application of biomimetic hydrogels are outlined.
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