细胞外小泡
结直肠癌
生物标志物
化学
癌症
胞外囊泡
微泡
医学
癌症研究
计算生物学
生物化学
生物
小RNA
细胞生物学
内科学
基因
作者
Jinye Xie,Shu Xing,Hong‐Bo Jiang,Zhang Jia-ju,D W Li,Shiqiong Niu,Zhijian Huang,Haofan Yin
出处
期刊:iScience
[Elsevier]
日期:2024-04-01
卷期号:27 (4): 109612-109612
标识
DOI:10.1016/j.isci.2024.109612
摘要
Extracellular vesicles (EVs) were promising circulating biomarkers for multiple diseases, but whether serum EVs-derived proteins could be used as a reliable tumor biomarker for colorectal cancer (CRC) remained inconclusive. In this study, we identified CXCL4 by a 4D data-independent acquisition-based quantitative proteomics assay of serum EVs-derived proteins in 40 individuals and subsequently analyzed serum EVs-derived CXCL4 levels by ELISA in 2 cohorts of 749 individuals. The results revealed that EVs-derived CXCL4 levels were dramatically elevated in CRC patients than in benign colorectal polyp patients or healthy controls (HC). Furthermore, receiver operating characteristic curves revealed that EVs-derived CXCL4 exhibited superior diagnostic performance with area under the curve of 0.948 in the training cohort. Additionally, CXCL4 could effectively distinguish CRC in stage I/II from HC. Notably, CRC patients with high levels of EVs-derived CXCL4 have shorter 2-year progression-free survival than those with low levels. Overall, our findings demonstrated that serum EVs-derived CXCL4 was a candidate diagnostic and prognostic biomarker for CRC.
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