基因
戒毒(替代医学)
生物
异型生物质的
新陈代谢
生物转化
代谢途径
下调和上调
光合作用
生物化学
化学
酶
医学
病理
替代医学
作者
Xiao Dong Wang,Chen Yi Zhang,Yi Yuan,Yi Fei Hua,Tadao Asami,Yi-Zhuo Qin,Xiao Hui Xiong,Jian Liang Zhu,Yi Chen Lu
标识
DOI:10.1021/acs.jafc.2c05142
摘要
Diuron [DU; 3-(3,4-dichlorophenyl)-1,1-dimethylurea], a widely used herbicide for weed control, arouses ecological and health risks due to its environment persistence. Our findings revealed that DU at 0.125-2.0 mg L-1 caused oxidative damage to rice. RNA-sequencing profiles disclosed a globally genetic expression landscape of rice under DU treatment. DU mediated downregulated gene encoding photosynthesis and biosynthesis of protein, fatty acid, and carbohydrate. Conversely, it induced the upregulation of numerous genes involved in xenobiotic metabolism, detoxification, and anti-oxidation. Furthermore, 15 DU metabolites produced by metabolic genes were identified, 7 of which include two Phase I-based and 5 Phase II-based derivatives, were reported for the first time. The changes of resistance-related phytohormones, like JA, ABA, and SA, in terms of their contents and molecular-regulated signaling pathways positively responded to DU stress. Our work provides a molecular-scale perspective on the response of rice to DU toxicity and clarifies the biotransformation and degradation fate of DU in rice crops.
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