核梭杆菌
癌变
结直肠癌
免疫系统
癌症研究
癌症
医学
生物
免疫学
微生物学
内科学
细菌
遗传学
牙龈卟啉单胞菌
作者
Nasser Hashemi Goradel,Siamak Heidarzadeh,Samira Jahangiri,Bagher Farhood,Keywan Mortezaee,Neda Khanlarkhani,Babak Negahdari
摘要
Abstract Colorectal cancer (CRC) is the third most prevalent cancer in the world. There are many risk factors involved in CRC. According to recent findings, the tumor microenvironment and feces samples of patients with CRC are enriched by Fusobacterium nucleatum . Thus, F. nucleatum is proposed as one of the risk factors in the initiation and progression of CRC. The most important mechanisms of Fusobacterium nucleatum involved in CRC carcinogenesis are immune modulation (such as increasing myeloid‐derived suppressor cells and inhibitory receptors of natural killer cells), virulence factors (such as FadA and Fap2), microRNAs (such as miR‐21), and bacteria metabolism. The aim of this review was to evaluate the mechanisms underlying the action of F. nucleatum in CRC.
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