Mitochondrial and ribosomal biogenesis are new hallmarks of stemness, oncometabolism and biomass accumulation in cancer: Mito‐stemness and ribo‐stemness features

癌症干细胞 癌症研究 乳腺癌 生物 CD44细胞 癌细胞 癌症 干细胞 转分化 线粒体生物发生 激光捕获显微切割 细胞生物学 细胞 线粒体 基因表达 遗传学 基因
作者
Maria Peiris‐Pagès,Béla Ózsvári,Federica Sotgia,Michael P. Lisanti
出处
期刊:Aging [Impact Journals LLC]
卷期号:11 (14): 4801-4835 被引量:10
标识
DOI:10.18632/aging.102054
摘要

Social cues, such as eye gaze and pointing fingers, can increase the prioritisation of specific locations for cognitive processing.A previous study using a manual reaching task showed that, although both gaze and pointing cues altered target prioritisation (reaction times [RTs]), only pointing cues affected action execution (trajectory deviations).These differential effects of gaze and pointing cues on action execution could be because the gaze cue was conveyed through a disembodied head; hence, the model lacked the potential for a body part (i.e., hands) to interact with the target.In the present study, the image of a male gaze model, whose gaze direction coincided with two potential target locations, was centrally presented.The model either had his arms and hands extended underneath the potential target locations, indicating the potential to act on the targets (Experiment 1), or had his arms crossed in front of his chest, indicating the absence of potential to act (Experiment 2).Participants reached to a target that followed a nonpredictive gaze cue at one of three stimulus onset asynchronies.RTs and reach trajectories of the movements to cued and uncued targets were analysed.RTs showed a facilitation effect for both experiments, whereas trajectory analysis revealed facilitatory and inhibitory effects, but only in Experiment 1 when the model could potentially act on the targets.The results of this study suggested that when the gaze model had the potential to interact with the cued target location, the model's gaze affected not only target prioritisation but also movement execution.

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