多巴胺能
多巴胺
神经科学
慢性疼痛
多巴胺能途径
医学
多巴胺受体
神经递质
心理学
中枢神经系统
作者
Changsheng Li,Sufang Liu,Xihua Lu,Feng Tao
标识
DOI:10.2174/1570159x17666190430102531
摘要
Pain, especially when chronic, is a common reason patients seek medical care and it affects the quality of life and well-being of the patients. Unfortunately, currently available therapies for chronic pain are often inadequate because the neurobiological basis of such pain is still not fully understood. Although dopamine has been known as a neurotransmitter to mediate reward and motivation, accumulating evidence has shown that dopamine systems in the brain are also involved in the central regulation of chronic pain. Most importantly, descending dopaminergic pathways play an important role in pain modulation. In this review, we discuss dopamine receptors, dopaminergic systems in the brain, and the role of descending dopaminergic pathways in the modulation of different types of pain.
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