沙利度胺
神经毒性
感觉系统
医学
累积剂量
感觉神经病变
药理学
内科学
神经科学
毒性
心理学
多发性骨髓瘤
作者
Guido Cavaletti,Alessandro Beronio,Lizia Reni,Elisabetta Ghiglione,Angelo Schenone,Chiara Briani,Gabriella Zara,Dario Cocito,G. Isoardo,P. Ciaramitaro,R. Plasmati,Francesca Pastorelli,M. Frigo,M. Piatti,M. Carpo
出处
期刊：Neurology
[Lippincott Williams & Wilkins]
日期：2004-06-22
卷期号：62 (12): 2291-2293
被引量：134
标识
DOI：10.1212/wnl.62.12.2291
摘要
The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.
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