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Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity

胶质细胞源性神经生长因子 内分泌学 内科学 神经营养因子 胰岛素抵抗 脂肪组织 生物 脂肪因子 化学 受体 胰岛素 医学
作者
Simon M. Mwangi,Behtash Ghazi Nezami,Blessing Obukwelu,Mallappa Anitha,Smitha Marri,Ping Fu,Monica Epperson,Ngoc‐Anh Le,Malathy Shanmugam,Shanthi V. Sitaraman,Yu–Hua Tseng,Frank A. Anania,Shanthi Srinivasan
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology [American Physiological Society]
卷期号:306 (6): G515-G525 被引量:32
标识
DOI:10.1152/ajpgi.00364.2013
摘要

Obesity is a growing epidemic with limited effective treatments. The neurotrophic factor glial cell line-derived neurotrophic factor (GDNF) was recently shown to enhance β-cell mass and improve glucose control in rodents. Its role in obesity is, however, not well characterized. In this study, we investigated the ability of GDNF to protect against high-fat diet (HFD)-induced obesity. GDNF transgenic (Tg) mice that overexpress GDNF under the control of the glial fibrillary acidic protein promoter and wild-type (WT) littermates were maintained on a HFD or regular rodent diet for 11 wk, and weight gain, energy expenditure, and insulin sensitivity were monitored. Differentiated mouse brown adipocytes and 3T3-L1 white adipocytes were used to study the effects of GDNF in vitro. Tg mice resisted the HFD-induced weight gain, insulin resistance, dyslipidemia, hyperleptinemia, and hepatic steatosis seen in WT mice despite similar food intake and activity levels. They exhibited significantly (P<0.001) higher energy expenditure than WT mice and increased expression in skeletal muscle and brown adipose tissue of peroxisome proliferator activated receptor-α and β1- and β3-adrenergic receptor genes, which are associated with increased lipolysis and enhanced lipid β-oxidation. In vitro, GDNF enhanced β-adrenergic-mediated cAMP release in brown adipocytes and suppressed lipid accumulation in differentiated 3T3L-1 cells through a p38MAPK signaling pathway. Our studies demonstrate a novel role for GDNF in the regulation of high-fat diet-induced obesity through increased energy expenditure. They show that GDNF and its receptor agonists may be potential targets for the treatment or prevention of obesity.
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