医学
围产期窒息
窒息
脂质运载蛋白
脐带
胎龄
白细胞
生物标志物
肌酐
基数超额
内科学
胃肠病学
麻醉
内分泌学
怀孕
免疫学
生物化学
化学
生物
遗传学
作者
Piotr Surmiak,Małgorzata Baumert,Małgorzata Fiala,Kinga Sypniewska,Zofia Walencka,Agnieszka Łukomska,Karolina Karcz
摘要
Recent reports have revealed increased concentration of neutrophil gelatinase-associated lipocalin (NGAL) in cardiovascular diseases and after episodes of hypoxia. We hypothesized that elevated plasma NGAL levels could be a result of vascular endothelial injury due to perinatal asphyxia.Ninety-three newborns with a gestational age > or = 37 weeks, of which 32 newborns were asphyxiated (study group), and 61 were healthy children (control group), were enrolled in the study Serum NGAL, lactate and creatinine concentrations, acid-base balance, neutrophil and white blood cell count were measured in the umbilical cord blood.Asphyxiated newborns had a significantly lower pH value (7.0 vs. 7.3, p < 0.001), lower HCO3 (15.8 mmol/L vs. 23.2 mmol/L; p < 0.001) and higher lactate concentrations (7.5 mmol/L vs. 2.3 mmol/L; p < 0.001), as compared to controls. Neutrophil count (10.3 x 109/L vs. 6.5 x 109/L; p = 0.02) and NGAL concentration (122.5 ng/mL vs. 24.3 ng/ mL p < 0.001) were elevated in asphyxiated newborns as compared to healthy children.The measurement of NGAL in the umbilical blood can be a valuable biomarker of perinatal asphyxia in neonates.
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