Adrenal rest tumor of the liver: A case report with immunohistochemical investigation of steroidogenesis

Abstract A case of adrenal rest tumor arising in the liver of a 62‐year‐old male with chronic hepatitis type C is reported. The tumor was clinically non‐functioning and required distinction from hepatocellular carcinoma. The yellowish–brown tumor measured 25 × 18 × 15 mm and was located in the subcapsular portion of the right hepatic lobe. Histologically, the tumor presented features similar to those of the adrenal cortex and was predominantly composed of pale cells. Electron micrograph revealed lipid droplets and mitochondria with tubulo–vesicular cristae, consistent with the characteristics of steroid‐producing cells. Immunohistochemically, the tumor expressed the adrenal 4 binding protein and a number of enzymes involved in the synthesis of adrenocortical steroids. At surgery, the right adrenal gland was present independently from the liver. This hepatic tumor was considered to be an adrenal rest tumor with steroidogenic capability.