Six new 10-pheynl-[11]cytochalasans, cytochalasins N - S from phomopsis SP.

From Phomopsis sp. (68-GO-164) six new cytochalasans named cytochalasins N, O, P, Q, R and S were isolated, together with the four known compounds, epoxycytochalasins H and J and cytochalasins H and J. The structures (5 – 10) of the new compounds as 10-phenyl-[11]cytochalasans were determined from spectral data, especially 1H and 13C NMR, and by chemical correlation with known compounds. Cytochalasins P, Q, R and S (7 – 10) have novel diol-type structures in the cyclohexane part of the molecules.