糖异生
盲肠
琥珀酸
肠道菌群
葡萄糖稳态
生物化学
平衡
短链脂肪酸
发酵
丁酸盐
新陈代谢
化学
生物
内科学
内分泌学
胰岛素
医学
胰岛素抵抗
作者
Filipe De Vadder,Petia Kovatcheva‐Datchary,Carine Zitoun,Adeline Duchampt,Fredrik Bäckhed,Gilles Mithieux
标识
DOI:10.1016/j.cmet.2016.06.013
摘要
Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was identified as a substrate for intestinal gluconeogenesis (IGN), a process that improves glucose homeostasis. Accordingly, dietary succinate improved glucose and insulin tolerance in wild-type mice, but those effects were absent in mice deficient in IGN. Conventional mice colonized with the succinate producer Prevotella copri exhibited metabolic benefits, which could be related to succinate-activated IGN. Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN.
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