Commercial supply chains and donor funded supply chains are driven by distinctive mechanisms and purposes, and the factors that make the operational environment of donor funded supply chains unpredictable, complex and dynamic, differ from those that cause this complexity in a commercial supply chain environment. Although literature contains several theories and frameworks to assist in the design, measurement and management of commercial supply chains, there is a significant research gap related to the formal study of donor funded supply chains. In this research, several examples of donor funded supply chains are investigated in order to systematically compare and highlight the key differences between donor funded supply chains and commercial supply chains.