癌变
癌症研究
血管生成
癌症
细胞凋亡
医学
肿瘤进展
信号通路
信号转导
肿瘤科
内科学
生物
细胞生物学
生物化学
作者
Chen Li,Hui Geng,Linhua Ji,Xiaojing Ma,Qichao Yin,Hua Xiong
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2019-12-16
卷期号:19 (14): 1687-1694
被引量:15
标识
DOI:10.2174/1871520619666190705151542
摘要
Cancer kills nearly 9,000,000 people worldwide, and its mortality was reported up to 28% in the past decade. Few available tumor markers have been known to help early stage diagnosis. In this study, Endocan was taken as a novel tumor marker, which has been found in many cancers related to cancer cell proliferation, neoangiogenesis, etc. Methods: Studies on Endocan and its correlation with cancer were reviewed, and key points of meaningful studies on the structure, pathways and targeted agents of Endocan were drawn.Endocan leads to tumorigenesis and promotes tumor cells proliferation via HGF/SF signal transmission pathway, suppresses tumor cells apoptosis via NF-κB signaling pathway and promotes angiogenesis within tumors via VEGF and HIF pathway. Medicine suppressing the expression of Endocan could prevent tumorigenesis and even improve survival rate of mice with tumor significantly.Endocan is capable of promoting prognosis of cancer patients. Moreover, Endocan is supposed to a potential target of tumor-targeted therapy.
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