光动力疗法
肿瘤微环境
体内
活性氧
透明质酸
癌症研究
化学
缺氧(环境)
细胞凋亡
癌细胞
医学
CD44细胞
肿瘤缺氧
体外
癌症
生物化学
生物
氧气
肿瘤细胞
放射治疗
内科学
生物技术
有机化学
解剖
作者
Yingkai Tao,Xiaoyang Hou,Huan Gao,Xin Zhang,Fengmei Zuo,Yun Wang,Xinxin Li,Jun Guan
出处
期刊:Nanomedicine
日期:2021-02-01
卷期号:16 (3): 221-235
被引量:6
标识
DOI:10.2217/nnm-2020-0096
摘要
Background: The hypoxia of the tumor microenvironment (TME), low transfer efficiency of photosensitizers and limited diffusion distance of reactive oxygen species restrict the application of photodynamic therapy (PDT). Aim: To produce TME-responsive and effective nanoparticles for sensitizing PDT. Materials & methods: CD44 and mitochondria grade-targeted hyaluronic acid (HA)-triphenylphosphine (TPP)-aminolevulinic acid (ALA)-catalase (CAT) nanoparticles (HTACNPs) were synthesized via a modified double-emulsion method. In vitro and in vivo experiments were performed to investigate the antitumor efficacy of HTACNP-mediated PDT. Results: HTACNPs specifically targeted MV3 cells and the mitochondria and produced O 2 to relieve TME hypoxia. HTACNP-mediated PDT produced reactive oxygen species to induce irreversible cell apoptosis. HTACNP-PDT inhibited melanoma growth effectively in vivo. Conclusion: HTACNP-mediated PDT improved TME hypoxia and effectively enhanced PDT for cancer.
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