化学
抗菌剂
多细胞生物
抗菌肽
计算生物学
抗生素耐药性
抗生素
主题(音乐)
微生物学
生物化学
生物
基因
声学
物理
作者
Jasmin Portelinha,Searle S. Duay,Seung I. Yu,Kara Heilemann,M. Daben J. Libardo,Samuel A. Juliano,Jonathan L. Klassen,Alfredo M. Angeles‐Boza
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-02-01
卷期号:121 (4): 2648-2712
被引量:55
标识
DOI:10.1021/acs.chemrev.0c00921
摘要
The emergence of new pathogens and multidrug resistant bacteria is an important public health issue that requires the development of novel classes of antibiotics. Antimicrobial peptides (AMPs) are a promising platform with great potential for the identification of new lead compounds that can combat the aforementioned pathogens due to their broad-spectrum antimicrobial activity and relatively low rate of resistance emergence. AMPs of multicellular organisms made their debut four decades ago thanks to ingenious researchers who asked simple questions about the resistance to bacterial infections of insects. Questions such as “Do fruit flies ever get sick?”, combined with pioneering studies, have led to an understanding of AMPs as universal weapons of the immune system. This review focuses on a subclass of AMPs that feature a metal binding motif known as the amino terminal copper and nickel (ATCUN) motif. One of the metal-based strategies of hosts facing a pathogen, it includes wielding the inherent toxicity of copper and deliberately trafficking this metal ion into sites of infection. The sudden increase in the concentration of copper ions in the presence of ATCUN-containing AMPs (ATCUN-AMPs) likely results in a synergistic interaction. Herein, we examine common structural features in ATCUN-AMPs that exist across species, and we highlight unique features that deserve additional attention. We also present the current state of knowledge about the molecular mechanisms behind their antimicrobial activity and the methods available to study this promising class of AMPs.
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