化学
生物分子
DNA
膜
生物系统
电子线路
纳米技术
计算生物学
生物化学
材料科学
工程类
生物
电气工程
作者
Tianqi Song,Shital Shah,Hieu Bui,Sudhanshu Garg,Abeer Eshra,Daniel Fu,Ming Yang,Reem Mokhtar,John H. Reif
摘要
DNA is a highly programmable biomolecule and has been used to construct biological circuits for different purposes. An important development of DNA circuits is to process the information on receptors on cell membranes. In this Communication, we introduce an architecture to program localized DNA-based biomolecular reaction networks on cancer cell membranes. Based on our architecture, various types of reaction networks have been experimentally demonstrated, from simple linear cascades to reaction networks of complex structures. These localized DNA-based reaction networks can be used for medical applications such as cancer cell detection. Compared to prior work on DNA circuits for evaluating cell membrane receptors, the DNA circuits made by our architecture have several major advantages including simpler design, lower leak, lower cost, and higher signal-to-background ratio.
科研通智能强力驱动
Strongly Powered by AbleSci AI