Erythema Multiforme Major: Case Report

Erythema Multiforme is an acute inflammatory disease of the skin and mucous membranes that causes a variety of skin lesions – hence the name multiforme. It is a blistering, ulcerative condition of uncertain etiopathogenesis. Hall mark of this is the iris or target lesion. EM may present within a wide spectrum of severity. Among the many etiologic factors the most common triggers for episodes of EM are herpes simplex virus and drug reactions. Drugs are reported in many documented cases of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis. Sulfa drugs are the most common triggers. Here is the case of erythema multiforme major secondary to drug reaction with oral, skin and genital manifestations.