Shufeng Jiedu, a promising herbal therapy for moderate COVID-19:Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study

沃戈宁 药理学 医学 药品 抗病毒药物 2019年冠状病毒病(COVID-19) 病毒 免疫学 内科学 中医药 传染病(医学专业) 疾病 病理 替代医学 黄芩
作者
Lu Xia,Yujing Shi,Jie Su,Thomas Friedemann,Zhenggang Tao,Yunfei Lu,Yun Ling,Ying Lv,Ronghua Zhao,Zihan Geng,Xiaolan Cui,Hongzhou Lu,Sven Schröder
出处
期刊:Phytomedicine [Elsevier]
卷期号:85: 153390-153390 被引量:68
标识
DOI:10.1016/j.phymed.2020.153390
摘要

Shufeng Jiedu capsules (SFJDC), a patented herbal drug composed of eight medicinal plants, is used for the treatment of different viral respiratory tract infectious diseases. Based on its antiviral, anti-inflammatory and immunoregulatory activity in acute lung injury, SFJDC might be a promising candidate for the treatment of COVID-19.To evaluate the antiviral and anti-inflammatory properties and to discover the mechanism of action of SFJDC as a potential drug for the treatment of COVID-19. Furthermore, the study should determine the clinical effectiveness of SFJDC for the treatment of COVID-19.We analyzed the antiviral and anti-inflammatory effects of SFJDC in a HCoV-229E mouse model on lung index, virus load in the lung, the release of cytokines, and on T- and B-lymphocytes. The mechanism of action was further investigated by network analysis. Additionally, we investigated data from a clinical pragmatic real-world study for patients with confirmed COVID-19, to evaluate the clinical effect of SFJDC and to determine the best time to start the treatment.SFJDC significantly reduced the virus load in the lung of HCoV-229E mice (from 1109.29 ± 696.75 to 0 ± 0 copies/ml), decreased inflammatory factors IL-6, IL-10, TNF-α, and IFN-γ in the lung, and increased the amount of CD4+ and CD8+ cells in the blood compared to the model group. Network analysis revealed that SFJDC reduces the activity of NFκB via several signaling pathways. Quercetin, wogonin, and polydatin bind directly to the main protease (Mpro) of SARS-CoV-2. Clinical data showed that SFJDC, added to standard antiviral therapy (AVD), significantly reduced the clinical recovery time of COVID-19 and fatigue (from 3.55 ± 4.09 to 1.19 ± 2.28 days) as well as cough (from 5.67 ± 5.64 to 3.47 ± 3.75) days compared to AVD alone. SFJDC therapy was significantly more effective when used within the first 8 days after the onset of symptoms.SFJDC might be a promising drug for the treatment of COVID-19, but large-scale randomized, double-blinded, placebo-controlled clinical trials are needed to complement the real-world evidence. It might be beneficial to start SFJDC treatment as early as possible in suspected cases of COVID-19.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
高海龙完成签到 ,获得积分10
12秒前
张尧摇摇摇完成签到 ,获得积分10
15秒前
和谐的果汁完成签到 ,获得积分10
19秒前
郭元强完成签到,获得积分10
22秒前
何晓俊完成签到,获得积分10
28秒前
木南大宝完成签到 ,获得积分10
32秒前
内向的火车完成签到 ,获得积分10
36秒前
豆子完成签到 ,获得积分10
38秒前
结实的小土豆完成签到 ,获得积分10
40秒前
Zhao完成签到 ,获得积分10
46秒前
灰鸽舞完成签到 ,获得积分10
49秒前
Cyrus完成签到 ,获得积分10
1分钟前
小蕾完成签到 ,获得积分10
1分钟前
yinlu完成签到 ,获得积分10
1分钟前
李崋壹完成签到 ,获得积分10
1分钟前
高大的莞完成签到 ,获得积分10
1分钟前
lqz0103完成签到,获得积分10
1分钟前
sisea完成签到 ,获得积分10
1分钟前
断章完成签到 ,获得积分10
1分钟前
兔兔完成签到 ,获得积分10
1分钟前
fujun0095完成签到,获得积分10
1分钟前
哈哈哈哈完成签到 ,获得积分10
1分钟前
陈俊雷完成签到 ,获得积分10
1分钟前
美满的小蘑菇完成签到 ,获得积分10
1分钟前
pzw完成签到 ,获得积分10
1分钟前
to完成签到 ,获得积分10
1分钟前
123完成签到 ,获得积分10
1分钟前
果宝特攻完成签到 ,获得积分10
1分钟前
不会游泳的鱼完成签到 ,获得积分10
1分钟前
江月年完成签到 ,获得积分10
1分钟前
大方的火龙果完成签到 ,获得积分10
1分钟前
感动白开水完成签到,获得积分10
2分钟前
郑洲完成签到 ,获得积分10
2分钟前
罗实完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
2分钟前
丰富梦容发布了新的文献求助10
2分钟前
2分钟前
2分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052652
求助须知:如何正确求助?哪些是违规求助? 2709874
关于积分的说明 7418267
捐赠科研通 2354453
什么是DOI,文献DOI怎么找? 1246090
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921