毛螺菌科
急性放射综合征
代谢组学
电离辐射
阿米福汀
胃肠道
生理学
人口
代谢组
生物
肠道菌群
放射治疗
造血
医学
免疫学
内科学
生物信息学
干细胞
细菌
厚壁菌
生物化学
环境卫生
辐照
遗传学
核物理学
物理
16S核糖体RNA
作者
Hao Guo,Wei-Chun Chou,Yunjia Lai,Kaixin Liang,Jason W. Tam,W. June Brickey,Liang Chen,Nathan D. Montgomery,Xin Li,Lauren Bohannon,Anthony D. Sung,Nelson J. Chao,Jonathan U. Peled,António Gomes,Marcel R.M. van den Brink,Matthew J. French,Andrew N. Macintyre,Gregory D. Sempowski,Xianming Tan,R. Balfour Sartor,Kun Lü,Jenny P.‐Y. Ting
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-10-30
卷期号:370 (6516)
被引量:242
标识
DOI:10.1126/science.aay9097
摘要
Ionizing radiation causes acute radiation syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose radiation to live normal life spans. These "elite-survivors" harbored distinct gut microbiota that developed after radiation and protected against radiation-induced damage and death in both germ-free and conventionally housed recipients. Elevated abundances of members of the bacterial taxa Lachnospiraceae and Enterococcaceae were associated with postradiation restoration of hematopoiesis and gastrointestinal repair. These bacteria were also found to be more abundant in leukemia patients undergoing radiotherapy, who also displayed milder gastrointestinal dysfunction. In our study in mice, metabolomics revealed increased fecal concentrations of microbially derived propionate and tryptophan metabolites in elite-survivors. The administration of these metabolites caused long-term radioprotection, mitigation of hematopoietic and gastrointestinal syndromes, and a reduction in proinflammatory responses.
科研通智能强力驱动
Strongly Powered by AbleSci AI